1315. Dental Discoloration and Enamel dysplasia after Tetracyclines Exposure in Children: A Nationwide Population-Based Study in Korea

Abstract Background Tetracycline (TC) is not recommended for pediatric use due to the risk of permanent teeth discoloration and enamel dysplasia. We aimed assess incidence dental abnormality in Korean children investigate whether was greater tetracycline-exposed compared general population. Methods This nationwide, population-based study using Health Insurance Review Assessment service database included (aged 0-12 years) who were prescribed tetracycline at least a day between January 2008 December 2020. evaluated rate inserted diagnosis codes dysplasia after 6 months prescription as primary outcome. Standardized ratio analyzed determine abnormalities exposed group population Korea. Results A total 56,990 patients with TCs exposure included, 3% under age 8 (n=1,735) while majority 97% ages 12 (n=55,255). The 0-7 year old 734 cases per 100,000 person-years, which about five times higher than 143 person-years 8-12 statistical significance (P< 0.001). 5-year cumulative years 4.1 % (95% CI, 3.0-5.7%) 5.7% 4.1–7.8%) 10-year period. In group, 0.8% 0.7-0.9%) 1.3% 1.1-1.4%). significantly increased TC-exposed (SIR = 1.08; 95% 0.69-1.60). Conclusion tooth lower previously suggested, particularly low one-fifth those 8, suggesting reconsideration limiting if clinically indicated. Disclosures All Authors: No reported disclosures.